Could be a form of ecstasy against cancer? ? TIME - Cancer ...

New research suggests that a modified form of MDMA ? better known as the illegal drug ecstasy known ? some types of blood cancer cells were able to kill. Prozac and similar antidepressants may also have similar anti-cancer potential.

It was known that Ecstasy and other drugs can attack cancer cells, but the problem is when using a drug such as MDMA to fight cancer, the dose that would be so great it would kill the patient.

?This is obviously not a very good treatment,? said John Gordon, professor of cellular immunology at the University of Birmingham said in Britain, said that knowing the toxic dose gave his team a place to start, when ?the redesign of the designer drug.?

one that is 100 times more potent against lymphoma cells than MDMA, and others, the 1,000-times stronger ? which do

Gordon and his colleagues developed analogues of MDMA. The experimental compounds are designed to reduce toxicity to brain cells ? and may, therefore, the high -. Simultaneous increase in activity against cancer cells

The researchers say that in laboratory tests that have been chemically synthesized compounds, the fats in the cell walls of blood cancer cells, including leukemia, lymphoma and myeloma tightened. That made it easier for the connections to get into cancer cells and kill them.

It was

Gordon?s team, which originally discovered the cancer-fighting properties of MDMA a few years ago. ?It started with the discovery that expressing lymphoma cell targets for neurotransmitters,? says Gordon.

?We have a surprising discovery that the serotonin transporter-Express and later found that they express the dopamine transporter expression,? he says and points to the neurotransmitters, serotonin and dopamine, which are normally found in the brain and play a role in mood and movement disorders. Both MDMA and antidepressants like Prozac affects these neurotransmitters, albeit in different ways. MORE: Ecstasy as Therapy: Have some of the negative effects Coated

Interestingly, receptors for serotonin, dopamine and other neurotransmitters not only found in the brain ? they are located on immune cells. This has researchers wondering whether psychotropic drugs that affect these receptors may also affect receptors on cancer cells growing by immune or brain cells. Gordon explains that the type of lymphoma cells in his laboratory studied immune cells called B-cells originate. B-cell tumors account for 80% to 90% of Non-Hodgkin?s lymphoma cases.

After publishing a paper suggesting that MDMA in a modified, less toxic doses might be a good anti-cancer strategy be, Gordon was by the Australian researcher Matthew Piggott, he is already in the modification of MDMA same direction, said contact. Piggott tried to develop a drug for the treatment of Parkinson?s disease ? a debilitating movement disorder that deficiencies in dopamine is -. With analogues of MDMA, based on reports that some patients had drastically reduced their symptoms and ecstasy

The two researchers decided, together with Piggott focus on the brain effects of drug and Gordon to make the cancer work. This month they published their new findings on the MDMA analogues in the Journal of Investigational New Drugs.

It is not clear whether the experimental compounds such as leisure, a high-producing ecstasy. Although full of trials is not yet completed their psychoactive properties, suggests preliminary work that the analogues are less likely to do so, as MDMA is.

But even if the new drug not be psychoactive, the grueling side effects, which may associated with most cancer treatment, is unlikely to feelings of peace and connection with others to challenge that. ?You could have worse side effects,? Gordon notes wryly. MORE

Gordon Research has also found that the antidepressant Prozac (fluoxetine) kill lymphoma cells in vitro, in doses the regularly used in the treatment of obsessive-compulsive disorder. Because the drug tends to concentrate in the brain, it can be especially useful against brain lymphoma, a rare and often deadly cancer that can affect people with AIDS.

The researchers were able to over the possibility that they patented the new cancer indication and drug companies tried to clinical trials of fluoxetine fund excited. Unfortunately, no takers. Prozac can get so cheap now that it no longer patented, that although the drug for cancer indications have been approved, it would not be profitable. ?My plea is to at least a glance if everything is failing in brain lymphoma. I see no danger to test Prozac, at least as a complement [to another treatment]. That to me would be the obvious be the first question, and if you give it some efficacy for brain lymphoma were seen, then the next step and [fund studies] go for other types of lymphoma, ?says Gordon. Maia Szalavitz is a health writer for TIME.com. Find it on Twitter at @ maiasz . You can continue the discussion on the TIME Healthland ?s Facebook page and on Twitter at @ time rural health .

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Source: http://blamecancer.org/health-information/could-be-a-form-of-ecstasy-against-cancer-time.html

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